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2.A.1.2.15
Arabinose (but not xylose) and isopropyl β-D-thio-galactopyranoside:H+ antiporter, YdeA (Koita and Rao 2012).

Accession Number:P31122
Protein Name:YdeA aka SOTB aka B1528
Length:396
Molecular Weight:42538.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Isopropyl beta-D-thio-galactopyranoside, Arabinose, H+

Cross database links:

Genevestigator: P31122
EchoBASE: EB1592
EcoGene: EG11636
eggNOG: COG2814
HEGENOM: HBG732715
RefSeq: AP_002149.1    NP_416045.1   
Entrez Gene ID: 947218   
Pfam: PF07690   
BioCyc: EcoCyc:YDEA-MONOMER    ECOL168927:B1528-MONOMER   
KEGG: ecj:JW1521    eco:b1528   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015144 F:carbohydrate transmembrane transporter acti...
GO:0015292 F:uniporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (7)

[1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.”  Aiba H.et.al.   9097039
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.”  Cohen S.P.et.al.   8383113
[5] “Transcriptional activation of ydeA, which encodes a member of the major facilitator superfamily, interferes with arabinose accumulation and induction of the Escherichia coli arabinose PBAD promoter.”  Bost S.et.al.   10094697
[6] “Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside.”  Carole S.et.al.   10438792
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTNTVSRKV AWLRVVTLAV AAFIFNTTEF VPVGLLSDIA QSFHMQTAQV GIMLTIYAWV 
61:	VALMSLPFML MTSQVERRKL LICLFVVFIA SHVLSFLSWS FTVLVISRIG VAFAHAIFWS 
121:	ITASLAIRMA PAGKRAQALS LIATGTALAM VLGLPLGRIV GQYFGWRMTF FAIGIGALIT 
181:	LLCLIKLLPL LPSEHSGSLK SLPLLFRRPA LMSIYLLTVV VVTAHYTAYS YIEPFVQNIA 
241:	GFSANFATAL LLLLGGAGII GSVIFGKLGN QYASALVSTA IALLLVCLAL LLPAANSEIH 
301:	LGVLSIFWGI AMMIIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA LVGNQVSLHW 
361:	SMSMIGYVGA VPAFAALIWS IIIFRRWPVT LEEQTQ