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2.A.1.2.17
Fluconazole:H+ antiporter

Accession Number:P38124
Protein Name:Flr1 aka YBR008C aka YBR0120
Length:548
Molecular Weight:61629.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fluconazole, H+

Cross database links:

Genevestigator: P38124
eggNOG: fuNOG06398
HEGENOM: HBG676874
DIP: DIP-4503N
RefSeq: NP_009562.1   
Entrez Gene ID: 852293   
Pfam: PF07690   
KEGG: sce:YBR008C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (2)

[1] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[2] “AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily.”  Alarco A.-M.et.al.   9235926

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVYTSTYRHT IVVDLLEYLG IVSNLETLQS AREDETRKPE NTDKKECKPD YDIECGPNRS 
61:	CSESSTDSDS SGSQIEKNDP FRVDWNGPSD PENPQNWPLL KKSLVVFQIM LLTCVTYMGS 
121:	SIYTPGQEYI QEEFHVGHVV ATLNLSLYVL GYGLGPIIFS PLSETARYGR LNLYMVTLFF 
181:	FMIFQVGCAT VHNIGGLIVM RFISGILCSP SLATGGGTVA DIISPEMVPL VLGMWSAGAV 
241:	AAPVLAPLLG AAMVDAKNWR FIFWLLMWLS AATFILLAFF FPETQHHNIL YRRALKLRKE 
301:	TGDDRYYTEQ DKLDREVDAR TFLINTLYRP LKMIIKEPAI LAFDLYIAVA YGCFYLFFEA 
361:	FPIVFVGIYH FSLVEVGLAY MGFCVGCVLA YGLFGILNMR IIVPRFRNGT FTPEAFLIVA 
421:	MCVCWCLPLS LFLFGWTARV HWILPVISEV FFVLAVFNIF QATFAYLATC YPKYVASVFA 
481:	GNGFCRASFA CAFPLFGRAM YDNLATKNYP VAWGSSLVGF LTLGLAIIPF ILYKYGPSLR 
541:	TRSSYTEE