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2.A.1.2.2
Cycloheximide:H+ antiporter

Accession Number:P32071
Protein Name:CyhR
Length:552
Molecular Weight:61366.00
Species:Candida maltosa (Yeast) [5479]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cycloheximide, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015238 F:drug transmembrane transporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0006835 P:dicarboxylic acid transport
GO:0015893 P:drug transport
GO:0046677 P:response to antibiotic
GO:0046898 P:response to cycloheximide
GO:0055085 P:transmembrane transport

References (1)

[1] “Cloning and sequence analysis of a Candida maltosa gene which confers resistance to cycloheximide.”  Sasnauskas K.et.al.   1628836

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAFIKDSFW GQIIYRLSGR KLFRHNDELP DYVVPEKYLL DPKEEVLNSS DKSQSSENKE 
61:	QTEGDQATIQ NEPASEHIIV TWDGDDDPEN PYNWPFAWKA IAAMQIGFLT VSVYMASAIY 
121:	TPGVEEIMNQ FNINSTLATL PLTMFVIGYG IGPLFWSPLS ENSRIGRTPL YIITLFIFFI 
181:	LQIPTALSNH IAGLSVLRVI AGFFAAPALS TGGASYGDFI AMHYYSIALG VWSIFAVAGP 
241:	SIGPLIGAAV INRSHDADGW RWSFWFMAIL SGVCFIVLSF SLPETYGKTL LRRKAERLRK 
301:	LTGNNRIISE GELEDGHKTT SQVVSSLLWR PLEITMLEPV VFLIDIYIAL VYSIMYLIFE 
361:	SVPIVYAGIH HFTLVEMGAT YVSTIIGIII GGAIYLPTVY YKFTKKLLAG QNVTPEVFLP 
421:	PAIFGAICMP IGVFIFGWTS SPDINWFVPL IGMALFAVGA FIIFQTLFNY MAVSFKVEYL 
481:	ASVFSSNAFF RSVSAGAFPL FGRALYNNLS IDKFPVGWGS SILGFISLGM IAIPVFFYLN 
541:	GPKLRARSKY AY