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2.A.1.2.21
The norfloxacin/enoxacin resistance protein, MdtH or YceL (Nishino and Yamaguchi 2001).

Accession Number:P69367
Protein Name:Multidrug resistance protein mdtH aka YceL aka B1065
Length:402
Molecular Weight:44363.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate norfloxacin, enoxacin

Cross database links:

Genevestigator: P69367
EchoBASE: EB3637
EcoGene: EG13878
eggNOG: COG0477
HEGENOM: HBG403347
RefSeq: AP_001691.1    NP_415583.4   
Entrez Gene ID: 946920   
Pfam: PF07690   
BioCyc: EcoCyc:B1065-MONOMER    ECOL168927:B1065-MONOMER   
KEGG: ecj:JW1052    eco:b1065   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (7)

[1] “Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli.”  Vlamis-Gardikas A.et.al.   9111025
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Analysis of a complete library of putative drug transporter genes in Escherichia coli.”  Nishino K.et.al.   11566977
[6] “Indole induces the expression of multidrug exporter genes in Escherichia coli.”  Hirakawa H.et.al.   15686558
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSRVSQARNL GKYFLLIDNM LVVLGFFVVF PLISIRFVDQ MGWAAVMVGI ALGLRQFIQQ 
61:	GLGIFGGAIA DRFGAKPMIV TGMLMRAAGF ATMGIAHEPW LLWFSCLLSG LGGTLFDPPR 
121:	SALVVKLIRP QQRGRFFSLL MMQDSAGAVI GALLGSWLLQ YDFRLVCATG AVLFVLCAAF 
181:	NAWLLPAWKL STVRTPVREG MTRVMRDKRF VTYVLTLAGY YMLAVQVMLM LPIMVNDVAG 
241:	APSAVKWMYA IEACLSLTLL YPIARWSEKH FRLEHRLMAG LLIMSLSMMP VGMVSGLQQL 
301:	FTLICLFYIG SIIAEPARET LSASLADARA RGSYMGFSRL GLAIGGAIGY IGGGWLFDLG 
361:	KSAHQPELPW MMLGIIGIFT FLALGWQFSQ KRAARRLLER DA