TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.2.24
The multidrug resistance efflux pump, CgMDR (exports fluoroquinolones and chloramphenicol) (Vardy et al., 2005)

Accession Number:Q8NRB5
Protein Name:Cgl1137
Length:405
Molecular Weight:42308.00
Species:Corynebacterium glutamicum [1718]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Fluoroquinolones, Chloramphenicol

Cross database links:

HEGENOM: HBG292421
RefSeq: NP_600365.1    YP_225429.1   
Entrez Gene ID: 1019122    3344352   
Pfam: PF07690    PF00083   
BioCyc: CGLU196627:CG1288-MONOMER   
KEGG: cgb:cg1288    cgl:NCgl1092   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.”  Kalinowski J.et.al.   12948626

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLTQKIELEA KPKIPEEIWV LVVAAFIIAL GYGLIAPILP QFVVGFDVSF AAASAVVSIF 
61:	AGARLLFAPM SGSLIDKIGS RRVYLTGLLT VAITTGLVAL AQEYWQILLL RGIAGIGSTM 
121:	FTVSAMGLIV KMAPVEIRGR CSSVYASSFL FGNIIGPVVG AAMSGLGMRW PFAIYGASVG 
181:	LAALVVWWRM PKTNDSLRKA DSNSVPALRF AEAIKDSAYR SALFSAFANG WSNFGVRVAV 
241:	LPLFAAAAFS NGGAIAGFAM AAFAAGNALC LQFAGDLSDR IGRKPMIISG LIVNAVFTAM 
301:	IGFGTEVWIL ITVSALAGAG AGLLNPSQQA VLADVIDSRP GGKVLANFQM AQDFGAIVGP 
361:	ILVGMIAEQA GFQIGFMLCG VISLLAAVAW IFGRETLPTA KVEQV