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2.A.1.2.30
The hippocampus abundant transcript-like 1 protein, HIATL1 (putative drug exporter)

Accession Number:Q5SR56
Protein Name:Hippocampus abundant transcript-like protein 1 HIATL1
Length:506
Molecular Weight:54545.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

Genevestigator: Q5SR56
eggNOG: prNOG10737
HEGENOM: HBG446950
RefSeq: NP_115947.2   
Entrez Gene ID: 84641   
Pfam: PF07690   
KEGG: hsa:84641   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (3)

[1] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG 
61:	LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT 
121:	CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV 
181:	SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD 
241:	PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL 
301:	SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP 
361:	AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV 
421:	PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED 
481:	IEPLLQDSSI WELSSFEEPG NQCTEL