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2.A.1.2.31
The multidrug transporter, QDR2, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake

Accession Number:P40474
Protein Name:QDR2
Length:542
Molecular Weight:59618.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Quinidine, Barban, Cisplatin, Bleomycin, K+

Cross database links:

Genevestigator: P40474
eggNOG: fuNOG04901
HEGENOM: HBG397984
DIP: DIP-5661N
RefSeq: NP_012145.1   
Entrez Gene ID: 854685   
Pfam: PF07690   
KEGG: sce:YIL121W   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0042802 F:identical protein binding
GO:0015559 ?:?
GO:0006855 P:drug transmembrane transport
GO:0010107 P:potassium ion import

References (7)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.”  Churcher C.M.et.al.   9169870
[2] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[3] “Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant.”  Vargas R.C.et.al.   15215105
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells.”  Vargas R.C.et.al.   17189489
[6] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP PHSRFSRSFK 
61:	TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN VTVVVYFVFQ GLAPTFMGGF 
121:	ADSLGRRPVV LVAIVIYFGA CIGLACAQTY AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT 
181:	RAERGGYVGY VAGFQVLGSA FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET 
241:	KRNISGNGSV TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE 
301:	ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC SIVIAGRYLN 
361:	WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP KYTFNIFKAR LQPAFVTLLL 
421:	SSSGFCAYGW CITVKAPLAA VLCMSGFASL FSNCILTFST TLIVDLFPTK TSTATGCLNL 
481:	FRCILSAVFI AALSKMVEKM KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG 
541:	VN