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2.A.1.2.35
The caffeine resistance protein 5 (Caf5) (Benko et al., 2004)

Accession Number:O94528
Protein Name:Caffeine resistance protein 5 aka Caf5
Length:531
Molecular Weight:59141.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Caffeine

Cross database links:

eggNOG: fuNOG06398
HEGENOM: HBG676874
RefSeq: NP_596314.1   
Entrez Gene ID: 2541116   
Pfam: PF07690   
KEGG: spo:SPBC609.04   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0031000 P:response to caffeine
GO:0055085 P:transmembrane transport

References (2)

[1] “The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.”  Benko Z.et.al.   14758541
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFLRETVFG ELVEYVSHNS NDNDLEKLRV WKDISKVDSN DSCSSESGDL KIHEVNSEGH 
61:	IIVRWDDAND PENPLNWPLW AKLVVTFDIC FLTFAVYVGS AIFTPGISEM QETMHVGTVP 
121:	VVLGLTLFVL GYAIGPLILS PLSEIPQVGR QKIYVLSLLV FVCLQIPTAL GSSLGVLLPM 
181:	RFLAGFFGSP ALATGGATLA DIWQPWLLPY FMCFWAIGAI GGPVLGPLLG GAMVVAESWR 
241:	WQFWLLMMIS GFALIVIFFF MPETSEWHIL YKRAKRFRKI TGNENYRTEA ELASSHLSVA 
301:	QLAKETIIRP IILSISEPIV LSLNIYIGLI YSILYLWFEA FPILFTSVYH FTIIENGLVY 
361:	LGILVGALIT LACYFVFLYK VMIPAFMASG GDFAPEGVLV ISFPATFFIP ICLFWFGWSG 
421:	RESVHWIVPI VSTLFYASGA FLMFQSMFQY LAASYPKYVA SVFAGNDLFR SAMAASFPLF 
481:	ARAMFNNTGP SYAPVAWGST ILGIVACLMI PIPFVLHKWG LKLRSRSKYA S