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2.A.1.2.36
The multidrug resistance protein Aqr1 (YNL065w) (exports short chain monocarboxylates but not more hydrophobic acids such as octonate and quinidine. Also exports ketoconazole and crystal violet (Tenreiro et al., 2002)).

Accession Number:P53943
Protein Name:Probable transporter Aqr1
Length:586
Molecular Weight:65296.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Short chain monocarboxylates, Ketoconazole, Crystal violet

Cross database links:

Genevestigator: P53943
eggNOG: fuNOG04901
HEGENOM: HBG397984
RefSeq: NP_014334.1   
Entrez Gene ID: 855660   
Pfam: PF07690   
KEGG: sce:YNL065W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008028 F:monocarboxylic acid transmembrane transport...
GO:0015239 ?:?
GO:0005515 F:protein binding
GO:0032973 P:amino acid export
GO:0015718 P:monocarboxylic acid transport
GO:0006855 P:drug transmembrane transport

References (7)

[1] “The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae.”  Bergez P.et.al.   8533472
[2] “”  Bergez P.et.al.   8904343
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[5] “Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs.”  Poehlmann R.et.al.   8701611
[6] “AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae.”  Tenreiro S.et.al.   11922628
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG TLSKTTTREI 
61:	EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW GMVAILTMCG FWSSLGSPIY 
121:	YPALRQLEKQ FNVDENMVNV TVVVYLLFQG ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS 
181:	IGLACAPSYG VIIFLRCIQS IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF 
241:	GSLIGAVLTA RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI 
301:	FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL LFAMWTLMLS 
361:	SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII DMYFKRKIKK FEQDKANGLI 
421:	PQDAEINMFK VRLVCLLPQN FLAVVAYLLF GWSIDKGWRI ESILITSFVC SYCAMSTLST 
481:	STTLLVDLYP TKSSTASSCF NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF 
541:	LMFIPMKYGM KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN