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2.A.1.2.4
Tetracycline:H+ antiporter

Accession Number:P02982
Protein Name:TCR1 aka TetA
Length:399
Molecular Weight:42241.00
Species:Escherichia coli [562]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

RefSeq: NP_957551.1    YP_190205.1   
Entrez Gene ID: 2716475    3244869   
Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0015992 P:proton transport
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Complete nucleotide sequence of Tn1721: gene organization and a novel gene product with features of a chemotaxis protein.”  Allmeier H.et.al.   1312499
[2] “The tetracycline resistance determinants of RP1 and Tn1721: nucleotide sequence analysis.”  Waters S.H.et.al.   6310527

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKPNRPLIVI LSTVALDAVG IGLIMPVLPG LLRDLVHSND VTAHYGILLA LYALMQFACA 
61:	PVLGALSDRF GRRPVLLVSL AGAAVDYAIM ATAPFLWVLY IGRIVAGITG ATGAVAGAYI 
121:	ADITDGDERA RHFGFMSACF GFGMVAGPVL GGLMGGFSPH APFFAAAALN GLNFLTGCFL 
181:	LPESHKGERR PLRREALNPL ASFRWARGMT VVAALMAVFF IMQLVGQVPA ALWVIFGEDR 
241:	FHWDATTIGI SLAAFGILHS LAQAMITGPV AARLGERRAL MLGMIADGTG YILLAFATRG 
301:	WMAFPIMVLL ASGGIGMPAL QAMLSRQVDE ERQGQLQGSL AALTSLTSIV GPLLFTAIYA 
361:	ASITTWNGWA WIAGAALYLL CLPALRRGLW SGAGQRADR