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2.A.1.2.42
The multidrug efflux pump, EmrD-3 (exports ethidium, linezolid, tetraphenylphosphonium chloride, rifampin, erythromycin, minocycline, trimethoprim, chloramphenicol, and rhodamine) (Smith et al., 2009).

Accession Number:Q9KMQ3
Protein Name:Multidrug resistance protein D
Length:379
Molecular Weight:40492.00
Species:Vibrio cholerae [666]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ethidium, Linezolid, Rifampin, Trimethoprim, Rhodamine, Chloramphenicol, Minocycline, erythromycin, Tetraphenylphosphonium chloride

Cross database links:

HEGENOM: HBG664445
RefSeq: NP_232665.1   
Entrez Gene ID: 2612083   
Pfam: PF07690   
KEGG: vch:VCA0267   

Gene Ontology

GO:0055085 P:transmembrane transport

References (1)

[1] “DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.”  Heidelberg J.F.et.al.   10952301

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTKPSLWLM VIMLMFPQIV ETIYSPVLGS IARSFSVSDA QAAQTLSVYF LAFALGVVIW 
61:	GVLADKWGRR PTMLVGLLIY GSATFIAMQT DSFTILMLAR VFSAFGIAVG SVVTQTILRD 
121:	VFSGHELRKV FSLMGIGISI SPVLGMLLGG QLAFAGGHQL VFLALFFIAL VLFVYNLCQL 
181:	PETQQVKPKI ALGCLVARMF KDRQVLLSAL LVALYNVALF SYYQLGAFIF SDLGLDAEQF 
241:	GYSGIALGLG SLIGSFLNKT LLAKQVPQRA LLLLAALLLI MGTIGVSLTL DSIGFVAAMI 
301:	LVVIAYGMAI PNILSTALVE YKSQAGSAGA LFGLLYYLLI GSGLALTGLV QRLGVVLLMC 
361:	AGITLLATLA RSSHIARLP