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2.A.1.2.47
The multidrug resistance efflux pump, HsMDR (YfmO2).  Exports drugs such as fluoroquinolones and chloramphenicol (Vardy et al., 2005).

Accession Number:Q9HS33
Protein Name:YfmO2
Length:420
Molecular Weight:42605.00
Species:Halobacterium sp. [2242]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fluoroquinolones, Chloramphenicol

Cross database links:

HEGENOM: HBG497573 HBG497573
RefSeq: NP_279495.1   
Entrez Gene ID: 1447279   
Pfam: PF07690   
BioCyc: HSP64091:VNG0427G-MONOMER   
KEGG: hal:VNG0427G    hal:VNG0427G   

Gene Ontology

GO:0055085 P:transmembrane transport
GO:0016021 C:integral to membrane

References (2)

[1] “Genome sequence of Halobacterium species NRC-1.”  Ng W.V.et.al.   11016950
[2] “Genome sequence of Halobacterium species NRC-1.”  Ng W.V.et.al.   11016950

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGLLDTDRRV LTLALARMAD ALGNSFLIVL LPAYIGEGYV AVDSLTGPLS VAGVSVLTVT 
61:	PALLIGIVLS TFGFLNSFLQ PFTGRLSDRT GVRKPFILGG LVLLALASGA YAFVSDYRLL 
121:	LVLRALQGIG AALTVPATVA LVSELGTTET RGSNFGVFNT FRLIGFGFGP IIAGVVLEVF 
181:	SFNAAFGVAA AGALTSFVLV ELTVDEPDTD GADAGDDLSI AVRGDDAVLD PVFALGIATV 
241:	AMGICIAMFA TLEAKINGKL DQSSILFGAE FGAVTLANVM FQVPIGTASD TYGRRPFIIA 
301:	GFIILIPATI AQGYAPTPAT MILARFVQGI AVAAVFAPSL AVAGDLAGAG ESGSTLAVLT 
361:	MGFGLGTAIG PLASGFLAAY GLATPFLIGG VLAALALAVV YTQVYETVPD ATAVSASTGD