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2.A.1.2.53
MDR pump, SLC22A18 in lung cancer cells (Lei et al., 2012).

Accession Number:Q96BI1
Protein Name:Solute carrier family 22 member 18
Length:424
Molecular Weight:44846.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

COG0477
Genevestigator: Q96BI1 Q96BI1
Entrez Gene ID: 5002   
Pfam: PF07690   
KEGG: hsa:5002    hsa:5002   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0044444 C:cytoplasmic part
GO:0016021 C:integral to membrane
GO:0005635 C:nuclear envelope
GO:0015238 F:drug transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0031625 F:ubiquitin protein ligase binding
GO:0007588 P:excretion
GO:0015695 P:organic cation transport

References (16)

[1] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.”  Lee M.P.et.al.   9751628
[2] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.”  Morisaki H.et.al.   9802569
[3] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.”  Cooper P.R.et.al.   9570947
[4] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.”  Dao D.et.al.   9499412
[5] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.”  Schwienbacher C.et.al.   9520460
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.”  Reece M.et.al.   9744804
[8] “Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.”  Yamada H.Y.et.al.   16314844
[9] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.”  Lee M.P.et.al.   9751628
[10] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.”  Morisaki H.et.al.   9802569
[11] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.”  Cooper P.R.et.al.   9570947
[12] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.”  Dao D.et.al.   9499412
[13] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.”  Schwienbacher C.et.al.   9520460
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.”  Reece M.et.al.   9744804
[16] “Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.”  Yamada H.Y.et.al.   16314844

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA 
61:	FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL ALYLLLAAAS SPALPGVYLL 
121:	FASRLPGALM HTLPAAQMVI TDLSAPEERP AALGRLGLCF GVGVILGSLL GGTLVSAYGI 
181:	QCPAILAALA TLLGAVLSFT CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV 
241:	PRIFLVKVAS NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS 
301:	HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD SMLIKAVSTS 
361:	DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ VAINTLVLLV LWRKPMPQRK 
421:	DKVR