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2.A.1.2.6
(Benomyl, cycloheximide, methotrexate, fluconazole, etc.):H+ antiporter, CaMDR1 (Basso et al., 2010; Cannon et al., 1998). MDR1 catalyzes efflux of commonly used azoles. The central cytoplasmic loop is critical for MDR function, but does not impart substrate specificity (Mandal et al., 2012).

Accession Number:P28873
Protein Name:BMRP aka CaMDR1 aka MDR1 aka BMR
Length:564
Molecular Weight:62930.00
Species:Candida albicans (Yeast) [5476]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate flucanazole, cycloheximide, benomyl, multiple drugs

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015238 F:drug transmembrane transporter activity
GO:0015893 P:drug transport
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate.”  Fling M.E.et.al.   2062311
[2] “Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate.”  Fling M.E.et.al.   2062311
[3] “Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate.”  Fling M.E.et.al.   2062311
[4] “Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate.”  Fling M.E.et.al.   2062311

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHYRFLRDSF VGRVTYHLSK HKYFAHPEEA KNYIIPEKYL ADYKPTLADD TSINFEKEEI 
61:	DNQGEPNSSQ SSSSNNTIVD NNNNNNNDVD GDKIVVTWDG DDDPENPQNW PTLQKAFFIF 
121:	QISFLTTSVY MGSAVYTPGI EELMHDFGIG RVVATLPLTL FVIGYGVGPL VFSPMSENAI 
181:	FGRTSIYIIT LFLFVILQIP TALVNNIAGL CILRFLGGFF ASPCLATGGA SVADVVKFWN 
241:	LPVGLAAWSL GAVCGPSFGP FFGSILTVKA SWRWTFWFMC IISGFSFVML CFTLPETFGK 
301:	TLLYRKAKRL RAITGNDRIT SEGEIENSKM TSHELIIDTL WRPLEITVME PVVLLINIYI 
361:	AMVYSILYLF FEVFPIYFVG VKHFTLVELG TTYMSIVIGI VIAAFIYIPV IRQKFTKPIL 
421:	RQEQVFPEVF IPIAIVGGIL LTSGLFIFGW SANRTTHWVG PLFGAATTAS GAFLIFQTLF 
481:	NFMGASFKPH YIASVFASND LFRSVIASVF PLFGAPLFDN LATPEYPVAW GSSVLGFITL 
541:	VMIAIPVLFY LNGPKLRARS KYAN