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2.A.1.2.63
Probable drug/proton antiporter YHK8

Accession Number:P38776
Protein Name:Probable drug/proton antiporter YHK8
Length:514
Molecular Weight:57838.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+, drugs

Cross database links:

Genevestigator: P38776
eggNOG: COG0477
HEGENOM: HOG000160689
DIP: DIP-8197N
Entrez Gene ID: 856444   
Pfam: PF07690   
KEGG: sce:YHR048W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0015893 P:drug transport
GO:0015992 P:proton transport

References (4)

[1] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[2] “Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae.”  Barker K.S.et.al.   12697649
[3] “Evolution of gene families: the multidrug resistance transporter genes in five related yeast species.”  Gbelska Y.et.al.   16630275
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE VTFNEDIADP 
61:	EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI IEHFHISHEV STLGITLYVF 
121:	GLGIGPLFLS PLSELYGRRI TFLYALTLSI IWQCLTIWSK TITGVMFGRF LSGFFGSAFL 
181:	SVAGGAIADI FDKDQIGIPM AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC 
241:	LVMIIFTIPE TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 
301:	LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI MVGMILSAPT 
361:	CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF IFAFTCYKHV HWIAPIIGSA 
421:	IFGSGVYFVF TGVFAYTVDA YRRYAASGMA CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG 
481:	FLLAMVTVAM IPVPFLFTKY GARLRAKSPY AWDD