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2.A.1.2.70
Multidrug resistance protein 1 (Multidrug-efflux transporter 1)

Accession Number:P33449
Protein Name:Multidrug resistance protein 1
Length:389
Molecular Weight:42232.00
Species:Bacillus subtilis (strain 168) [224308]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: COG0477
HEGENOM: HOG000266878
Entrez Gene ID: 938680   
Pfam: PF07690   
KEGG: bsu:BSU24010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (5)

[1] “Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.”  Neyfakh A.A.et.al.   1675788
[2] “A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates.”  Ahmed M.et.al.   7961792
[3] “Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes.”  Mizuno M.et.al.   8969508
[4] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[5] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKKNITLTI LLTNLFIAFL GIGLVIPVTP TIMNELHLSG TAVGYMVACF AITQLIVSPI 
61:	AGRWVDRFGR KIMIVIGLLF FSVSEFLFGI GKTVEMLFIS RMLGGISAAF IMPGVTAFIA 
121:	DITTIKTRPK ALGYMSAAIS TGFIIGPGIG GFLAEVHSRL PFFFAAAFAL LAAILSILTL 
181:	REPERNPENQ EIKGQKTGFK RIFAPMYFIA FLIILISSFG LASFESLFAL FVDHKFGFTA 
241:	SDIAIMITGG AIVGAITQVV LFDRFTRWFG EIHLIRYSLI LSTSLVFLLT TVHSYVAILL 
301:	VTVTVFVGFD LMRPAVTTYL SKIAGNEQGF AGGMNSMFTS IGNVFGPIIG GMLFDIDVNY 
361:	PFYFATVTLA IGIALTIAWK APAHLKAST