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2.A.1.2.75
Tetracycline resistance protein, class E (TetA(E))

Accession Number:Q07282
Protein Name:Tetracycline resistance protein, class E
Length:405
Molecular Weight:43413.00
Species:Escherichia coli [562]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015992 P:proton transport
GO:0046677 P:response to antibiotic

References (1)

[1] “Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins.”  Allard J.D.et.al.   8331085

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRTVMMALV IIFLDAMGIG IIMPVLPALL REFVGKANVA ENYGVLLALY AMMQVIFAPL 
61:	LGRWSDRIGR RPVLLLSLLG ATLDYALMAT ASVVWVLYLG RLIAGITGAT GAVAASTIAD 
121:	VTPEESRTHW FGMMGACFGG GMIAGPVIGG FAGQLSVQAP FMFAAAINGL AFLVSLFILH 
181:	ETHNANQVSD ELKNETINET TSSIREMISP LSGLLVVFFI IQLIGQIPAT LWVLFGEERF 
241:	AWDGVMVGVS LAVFGLTHAL FQGLAAGFIA KHLGERKAIA VGILADGCGL FLLAVITQSW 
301:	MVWPVLLLLA CGGITLPALQ GIISVRVGQV AQGQLQGVLT SLTHLTAVIG PLVFAFLYSA 
361:	TRETWNGWVW IIGCGLYVVA LIILRFFHPG RVIHPINKSD VQQRI