TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.2.8
(Spermidine; fluoroquinolones, acriflavin, chloramphenicol, ethidium bromide, etc.):H+ antiporter

Accession Number:P39843
Protein Name:BMR2 aka Blt aka BMT
Length:400
Molecular Weight:43424.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Spermidine, Fluoroquinolones, acriflavin, Chloramphenicol, ethidium bromide, H+

Cross database links:

HEGENOM: HBG710362
RefSeq: NP_390536.1   
Entrez Gene ID: 937646   
Pfam: PF07690   
KEGG: bsu:BSU26590   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.”  Ahmed M.et.al.   7608059
[2] “Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes.”  Mizuno M.et.al.   8969508
[3] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKKSINEQKT IFIILLSNIF VAFLGIGLII PVMPSFMKIM HLSGSTMGYL VAAFAISQLI 
61:	TSPFAGRWVD RFGRKKMIIL GLLIFSLSEL IFGLGTHVSI FYFSRILGGV SAAFIMPAVT 
121:	AYVADITTLK ERSKAMGYVS AAISTGFIIG PGAGGFIAGF GIRMPFFFAS AIALIAAVTS 
181:	VFILKESLSI EERHQLSSHT KESNFIKDLK RSIHPVYFIA FIIVFVMAFG LSAYETVFSL 
241:	FSDHKFGFTP KDIAAIITIS SIVAVVIQVL LFGKLVNKLG EKRMIQLCLI TGAILAFVST 
301:	VMSGFLTVLL VTCFIFLAFD LLRPALTAHL SNMAGNQQGF VAGMNSTYTS LGNIFGPALG 
361:	GILFDLNIHY PFLFAGFVMI VGLGLTMVWK EKKNDAAALN