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2.A.1.20.1
Sugar efflux transporter A, SetA.  Exports lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, α-methylglucoside and isopropyl β-thiogalactosides (IPTG); amino-glycosides, streptomycin and kanamycin are weakly expelled (Liu et al. 1999).  Regulated by SgrR (a transcriptional regulator of sgrS) and SgrS (a small RNA that represses trascription of setA).  These two regulatory genes are upstream of the setA gene.  Uses a pmf-dependent mechanism of energization.  Induced in response to glucose-phosphate stress which occurs when a sugar phosphates accumulate in the cytoplam (Sun and Vanderpool 2011).

Accession Number:P31675
Protein Name:SetA aka YabM aka B0070
Length:392
Molecular Weight:42713.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lactose, glucose, Aromatic glucosides, Galactosides, Cellobiose, Maltose, Alpha-methylglucosides, IPTG, Amino-glycosides, Streptomycin, Kanamycin

Cross database links:

Genevestigator: P31675
EchoBASE: EB1704
EcoGene: EG11754
eggNOG: COG0477
HEGENOM: HBG739814
RefSeq: AP_000734.1    YP_025293.1   
Entrez Gene ID: 944793   
Pfam: PF07690   
BioCyc: EcoCyc:B0070-MONOMER   
KEGG: ecj:JW0069    eco:b0070   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015542 F:sugar efflux transmembrane transporter acti...
GO:0015758 P:glucose transport
GO:0015767 P:lactose transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura T.et.al.   1630901
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “The identification of a new family of sugar efflux pumps in Escherichia coli.”  Liu J.Y.et.al.   10209755
[6] “Functional and biochemical characterization of Escherichia coli sugar efflux transporters.”  Liu J.Y.et.al.   10438463
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIWIMTMARR MNGVYAAFML VAFMMGVAGA LQAPTLSLFL SREVGAQPFW IGLFYTVNAI 
61:	AGIGVSLWLA KRSDSQGDRR KLIIFCCLMA IGNALLFAFN RHYLTLITCG VLLASLANTA 
121:	MPQLFALARE YADNSAREVV MFSSVMRAQL SLAWVIGPPL AFMLALNYGF TVMFSIAAGI 
181:	FTLSLVLIAF MLPSVARVEL PSENALSMQG GWQDSNVRML FVASTLMWTC NTMYIIDMPL 
241:	WISSELGLPD KLAGFLMGTA AGLEIPAMIL AGYYVKRYGK RRMMVIAVAA GVLFYTGLIF 
301:	FNSRMALMTL QLFNAVFIGI VAGIGMLWFQ DLMPGRAGAA TTLFTNSIST GVILAGVIQG 
361:	AIAQSWGHFA VYWVIAVISV VALFLTAKVK DV