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2.A.1.20.2
Efflux system, SetB, for lactose and glucose, but not IPTG or galactose (Liu et al. 1999).

Accession Number:P33026
Protein Name:SetB aka YeiO aka B2170
Length:393
Molecular Weight:42746.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lactose, glucose

Cross database links:

Genevestigator: P33026
EchoBASE: EB1969
EcoGene: EG12034
eggNOG: COG0477
HEGENOM: HBG739814
RefSeq: AP_002767.1    NP_416675.1   
Entrez Gene ID: 946673   
Pfam: PF07690   
BioCyc: EcoCyc:B2170-MONOMER    ECOL168927:B2170-MONOMER   
KEGG: ecj:JW2157    eco:b2170   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015542 F:sugar efflux transmembrane transporter acti...
GO:0007059 P:chromosome segregation
GO:0015758 P:glucose transport
GO:0015767 P:lactose transport
GO:0055085 P:transmembrane transport

References (5)

[1] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “The identification of a new family of sugar efflux pumps in Escherichia coli.”  Liu J.Y.et.al.   10209755
[5] “Functional and biochemical characterization of Escherichia coli sugar efflux transporters.”  Liu J.Y.et.al.   10438463

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP AMVGFFFTGS 
61:	AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA WNRNYFVLLF VGVFLSSFGS 
121:	TANPQMFALA REHADKTGRE AVMFSSFLRA QVSLAWVIGP PLAYALAMGF SFTVMYLSAA 
181:	VAFIVCGVMV WLFLPSMRKE LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP 
241:	LFIINELHLP EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML 
301:	MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR VGWIIAGSVA 
361:	GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV