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2.A.1.21.1
The macrolide (erythromycin; oleandomycin; azithromycin; telithromycin) efflux pump, MefA, of 405 aas and 12 TMSs (Cantón et al. 2005; Bley et al. 2011). Iannelli et al. 2018 suggested that MefA can function with an ATPase, MsrD (TC# 3.A.1.121.6), and therefore function as an ABC drug exporter.  However, the data presented seem inconsistent with this suggestion. The two genes encoding these two proteins are adjacent to each other, suggesting that they may function together (Iannelli et al. 2018).

Accession Number:P95827
Protein Name:MefA aka MEF
Length:405
Molecular Weight:44279.00
Species:Streptococcus pyogenes, and OS Streptococcus pneumoniae [1314]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate erythromycin, Oleandomycin, Azithromycin

Cross database links:

Pfam: PF05977   

References (3)

[1] “Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes.”  Clancy J.et.al.   8971709
[2] “The novel conjugative transposon tn1207.3 carries the macrolide efflux gene mef(A) in Streptococcus pyogenes.”  Santagati M.et.al.   12959402
[3] “Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus.”  Banks D.J.et.al.   14673771

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FASTA formatted sequence
1:	MEKYNNWKLK FYTIWAGQAV SLITSAILQM AIIFYLTEKT GSAMVLSMAS LLGFLPYAVF 
61:	GPAIGVLVDR HDRKKIMIGA DLIIAAAGSV LTIVAFYMEL PVWMVMIVLF IRSIGTAFHT 
121:	PALNAVTPLL VPEEQLTKCA GYSQSLQSIS YIVSPAVAAL LYSVWELNAI IAIDVLGAVI 
181:	ASITVAIVRI PKLGDRVQSL DPNFIREMQE GMAVLRQNKG LFALLLVGTL YMFVYMPINA 
241:	LFPLISMDYF NGTPVHISIT EISFASGMLI GGLLLGLFGN YQKRILLITA SIFMMGISLT 
301:	ISGLLPQSGF FIFVVCCAIM GLSVPFYSGV QTALFQEKIK PEYLGRVFSL TGSIMSLAMP 
361:	IGLILSALFA DRIGVNHWFL LSGTLIICIA IVCPMINEIR KLDLK