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2.A.1.21.12
Multidrug-efflux transporter, Rv1258c/MT1297, of 419 aas and 12 TMSs. Both Rv1634 and Rv1258c are believed to play major roles in drug resistance by altering the protein pump that is required to remove the active drugs from the bacterial cell (Panja et al. 2019).

Accession Number:P64783
Protein Name:Probable multidrug-efflux transporter Rv1258c/MT1297
Length:419
Molecular Weight:43287.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: NOG272961
HEGENOM: HOG000069090
Entrez Gene ID: 887056    924773   
Pfam: PF07690   
KEGG: mtc:MT1297    mtu:Rv1258c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015562 F:efflux transmembrane transporter activity
GO:0046677 P:response to antibiotic

References (4)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.”  De Rossi E.et.al.   12520088
[4] “Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump.”  Siddiqi N.et.al.   15057575

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRNSNRGPAF LILFATLMAA AGDGVSIVAF PWLVLQREGS AGQASIVASA TMLPLLFATL 
61:	VAGTAVDYFG RRRVSMVADA LSGAAVAGVP LVAWGYGGDA VNVLVLAVLA ALAAAFGPAG 
121:	MTARDSMLPE AAARAGWSLD RINGAYEAIL NLAFIVGPAI GGLMIATVGG ITTMWITATA 
181:	FGLSILAIAA LQLEGAGKPH HTSRPQGLVS GIAEGLRFVW NLRVLRTLGM IDLTVTALYL 
241:	PMESVLFPKY FTDHQQPVQL GWALMAIAGG GLVGALGYAV LAIRVPRRVT MSTAVLTLGL 
301:	ASMVIAFLPP LPVIMVLCAV VGLVYGPIQP IYNYVIQTRA AQHLRGRVVG VMTSLAYAAG 
361:	PLGLLLAGPL TDAAGLHATF LALALPIVCT GLVAIRLPAL RELDLAPQAD IDRPVGSAQ