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2.A.1.21.12
Probable multidrug-efflux transporter Rv1258c/MT1297

Accession Number:P64783
Protein Name:Probable multidrug-efflux transporter Rv1258c/MT1297
Length:419
Molecular Weight:43287.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: NOG272961
HEGENOM: HOG000069090
Entrez Gene ID: 887056    924773   
Pfam: PF07690   
KEGG: mtc:MT1297    mtu:Rv1258c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015562 F:efflux transmembrane transporter activity
GO:0046677 P:response to antibiotic

References (4)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.”  De Rossi E.et.al.   12520088
[4] “Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump.”  Siddiqi N.et.al.   15057575

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRNSNRGPAF LILFATLMAA AGDGVSIVAF PWLVLQREGS AGQASIVASA TMLPLLFATL 
61:	VAGTAVDYFG RRRVSMVADA LSGAAVAGVP LVAWGYGGDA VNVLVLAVLA ALAAAFGPAG 
121:	MTARDSMLPE AAARAGWSLD RINGAYEAIL NLAFIVGPAI GGLMIATVGG ITTMWITATA 
181:	FGLSILAIAA LQLEGAGKPH HTSRPQGLVS GIAEGLRFVW NLRVLRTLGM IDLTVTALYL 
241:	PMESVLFPKY FTDHQQPVQL GWALMAIAGG GLVGALGYAV LAIRVPRRVT MSTAVLTLGL 
301:	ASMVIAFLPP LPVIMVLCAV VGLVYGPIQP IYNYVIQTRA AQHLRGRVVG VMTSLAYAAG 
361:	PLGLLLAGPL TDAAGLHATF LALALPIVCT GLVAIRLPAL RELDLAPQAD IDRPVGSAQ