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2.A.1.21.2
The multidrug (erythromycin, tetracycline, puromycin, bleomycin) resistance protein, Cmr

Accession Number:Q79VC7
Protein Name:MULTIDRUG RESISTANCE PROTEIN
Length:459
Molecular Weight:49339.00
Species: [1718]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

HEGENOM: HBG286707
RefSeq: NP_601971.1    YP_227014.1   
Entrez Gene ID: 1020721    3345379   
Pfam: PF07690   
BioCyc: CGLU196627:CG3075-MONOMER   
KEGG: cgb:cg3075    cgl:NCgl2680   

Gene Ontology

GO:0055085 P:transmembrane transport

References (2)

[1] “A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli.”  Jager W.et.al.   9079937
[2] “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.”  Kalinowski J.et.al.   12948626

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSTFHKVLIN TMISNVTTGF LFFAVVFWMY LSTGNVALTG IVSGIYMGLI AVCSIFFGTV 
61:	VDHNRKKSVM LFSSVTTLVF YCLSALVWVF WLEEDGLSIG NTALWVFVSF ILIGSIVEHM 
121:	RNIALSTVVT LLVPEAERDK ANGLVGAVQG VGFLVTSVIA GSAIGFLGME ITLWICLGLS 
181:	LVALLHLLPI RVDEPEIITQ EDAQPTVSDD SVPTPTSDLA IVSKGIDLKG SMKIILSVPG 
241:	LLALVLFASF NNLIGGVYSA LMDPYGLELF SPQLWGLLLG LTSLGFIVGG AVISKTGLGK 
301:	NPVRTLLLVN VGVAFVGMLF AIREWWWLYI LGIFIFMAIT PAAEAAEQTI LQRVVPFRQQ 
361:	GRVFGLAMAV EMAANPLSTV IVAILAEAYL IPWMAGPGAD TIWGVILGEG KARGMALMFL 
421:	ASGAIMLVVV LLAFMSRSYR KLSQYYATTS QDIAGAAEK