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2.A.1.21.22
Macrolide efflux pump, MefE (Mef; MefA) of 405 aas.  Induced by erythromycin and the antimicrobial peptide, LL-37 (Zähner et al. 2010).  May act in conjunction with Mel (Q93QE4), an ABC-type ATPase that is encoded in the same operon with the mefA gene (Ambrose et al. 2005).

Accession Number:Q7BKK4
Protein Name:Macrolide efflux protein E
Length:405
Molecular Weight:43925.00
Species:Streptococcus pneumoniae [1313]
Number of TMSs:12
Substrate erythromycin, LL-37

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKYNNWKRK FYAIWAGQAV SLITSAILQM AIIFYLTEKT GSAMVLSMAS LVGFLPYAIL 
61:	GPAIGVLVDR HDRKKIMIGA DLIIAAAGAV LAIVAFCMEL PVWMIMIVLF IRSIGTAFHT 
121:	PALNAVTPLL VPEEQLTKCA GYSQSLQSIS YIVSPAVAAL LYSVWDLNAI IAIDVLGAVI 
181:	ASITVAIVRI PKLGNQVQSL EPNFIREMKE GVVVLRQNKG LFALLLLGTL YTFVYMPINA 
241:	LFPLISMEHF NGTPVHISIT EISFAFGMLA GGLLLGRLGG FEKHVLLITS SFFIMGTSLA 
301:	VSGILPPNGF VIFVVCCAIM GLSVPFYSGV QTALFQEKIK PEYLGRVFSL IGSIMSLAMP 
361:	IGLILSGFFA DKIGVNHWFL LSGILIIGIA IVCQMITEVR KLDLK