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2.A.1.21.3
The tetracycline resistance determinant, TetV

Accession Number:O31137
Protein Name:TetV
Length:419
Molecular Weight:44643.00
Species:Mycobacterium smegmatis [1772]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

RefSeq: YP_889433.1   
Entrez Gene ID: 4532468   
Pfam: PF05977   

References (1)

[1] “Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis.”  De Rossi E.et.al.   9687386

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRSPRPVAGW RVLAPFRIRE YRLLIAAVTL SIFAEGMWSV VMALQVIAID NDPASLSLVA 
61:	TCLGVGLVAF VLVGGITADR INQRTIIIAV EVVNFVTVAV ISALALLGVL KIWHMAVAAG 
121:	ILGIAAAFFF PAYSAILPRI LPPEQLLAAN GVEGVVRPVF QRSVGPAVAG MVIGATMPSI 
181:	GAVVVAVLFA LGLALLVATR PPAQPASEHH ERPHVLRDLR EGFAFVLKTP WLLWTVLFAS 
241:	MFVLVVLGPI EVLLPFIAQD RFADGARAYG FILAFFGIGS AMGALTVSSR RMPRRYLTTM 
301:	MLMWGLGSIP LVIVGYTSSF PLMAAATFVI GVTDGAGMVI WGTLLQRRVP TEMLGRVSSL 
361:	DFFVSLAFMP LSFAIVGPLS KVVSMEVIFA TAGLVPVAIA AVAFTAARMH RDEVANPLL