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2.A.1.21.6
The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e-07) with 2.A.1.21.5 and 22% identity (2xe-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.

Accession Number:Q46305
Protein Name:Tetracycline efflux protein
Length:420
Molecular Weight:46134.00
Species:Clostridium perfringens [1502]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

RefSeq: YP_001967742.1   
Entrez Gene ID: 6383111   
Pfam: PF07690   

Gene Ontology

GO:0055085 P:transmembrane transport

References (2)

[1] “The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.”  Sloan J.et.al.   8170402
[2] “Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens.”  Bannam T.L.et.al.   16788202

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVNKLSAYKT YLLFSAITAM CFSLVATVMM VYHIEIVHLN PLQLILVGTT LELACFIFEI 
61:	PTAIVADVYS RKLSIVIGGV LTGVGFILEG SISSFVFVLV AQIVWGLGST FISGSLEAWI 
121:	AEEEKNKDLD EIYIKGAQAG QIGAFIGIVL STVIANFSVR LPIIVSGVLF IILALFLWLY 
181:	MPENNFKPSA PGDLNTFKKM VYTFKSGLKF VKSKSIIMIL LAVTLFYGLS SEGYDRLSNA 
241:	HFLQDTTLPK LGNLSSVTWF GIFGILGMIL SFIVMHFMAK NLKNEDNRKN GKLLLCINIL 
301:	YISSMLIFAL TRNFSLMLIA YLATNTFRII NKPIFSAWLN GHIDDNSRAT VLSINGQMNS 
361:	LGQILGGPII GIIATNISVS IGIVCTSLLV TPVLVLYIVA MIIDKKVDDR VGGIDYEENN