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2.A.1.22.1
Synaptic vesicle neurotransmitter (e.g., dopamine) transporter, SV2.  This protein localizes to neurotransmitter-containing vesicles and has a nucleotide binding site (Yao and Bajjalieh 2009).

Accession Number:Q02563
Protein Name:SYV2 aka SV2
Length:742
Molecular Weight:82661.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q02563
eggNOG: roNOG15218
RefSeq: NP_476558.2   
Entrez Gene ID: 117559   
Pfam: PF07690    PF00083   
KEGG: rno:117559   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0030672 C:synaptic vesicle membrane
GO:0005515 F:protein binding
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0006836 P:neurotransmitter transport
GO:0055085 P:transmembrane transport

References (12)

[1] “The synaptic vesicle protein SV2 is a novel type of transmembrane transporter.”  Feany M.B.et.al.   1355409
[2] “Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system.”  Gingrich J.A.et.al.   1426240
[3] “SV2, a brain synaptic vesicle protein homologous to bacterial transporters.”  Bajjalieh S.M.et.al.   1519064
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin.”  Schivell A.E.et.al.   8910372
[6] “SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family.”  Janz R.et.al.   10625067
[7] “AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs.”  Haucke V.et.al.   10455054
[8] “Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin.”  Pyle R.A.et.al.   10747945
[9] “The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.”  Lynch B.A.et.al.   15210974
[10] “SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.”  Iezzi M.et.al.   16306227
[11] “SV2A and SV2C contain a unique synaptotagmin-binding site.”  Schivell A.E.et.al.   15866046
[12] “SV2 is the protein receptor for botulinum neurotoxin A.”  Dong M.et.al.   16543415

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE EEEDDDDFPA 
61:	PADGYYRGEG AQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 
121:	GVRGGLSDGE GPPGGRGEAQ RRKDREELAQ QYETILRECG HGRFQWTLYF VLGLALMADG 
181:	VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 
241:	VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 
301:	MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 
361:	FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGTWYQRW 
421:	GVRALSLGGQ VWGNFLSCFS PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 
481:	AARTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 
541:	SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LVNSTFLHNK EGCPLDVTGT GEGAYMVYFV 
601:	SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVLSCVSCF FLSFGNSESA MIALLCLFGG 
661:	VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 
721:	AALALGSSLA LKLPETRGQV LQ