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2.A.1.25.2
Cell wall degradation product (peptides and glycopeptides including N-acetylglucosaminyl β-1,4-anhydro-N-acetyl-muramyl-tripeptide) as well as penicillin derivative uptake porter, AmpG (Cheng and Park 2002).

Accession Number:P0AE16
Protein Name:Protein AmpG aka B0433
Length:491
Molecular Weight:53245.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate peptides, Glycopeptides, N-acetylglucosaminyl beta-1,4-anhydro-N-acetyl-muramyl-tripeptide, Penicillin derivatives

Cross database links:

Genevestigator: P0AE16
EchoBASE: EB2100
EcoGene: EG12183
eggNOG: COG0477
HEGENOM: HBG713261
RefSeq: AP_001083.1    NP_414967.1   
Entrez Gene ID: 946438   
Pfam: PF07690   
BioCyc: EcoCyc:AMPG-MONOMER    ECOL168927:B0433-MONOMER   
KEGG: ecj:JW0423    eco:b0433   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015295 F:solute:hydrogen symporter activity
GO:0000270 P:peptidoglycan metabolic process
GO:0015835 P:peptidoglycan transport
GO:0055085 P:transmembrane transport

References (5)

[1] “AmpG, a signal transducer in chromosomal beta-lactamase induction.”  Lindquist S.et.al.   8231804
[2] “The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers.”  Schmidt H.et.al.   7773404
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSSQYLRIFQ QPRSAILLIL GFASGLPLAL TSGTLQAWMT VENIDLKTIG FFSLVGQAYV 
61:	FKFLWSPLMD RYTPPFFGRR RGWLLATQIL LLVAIAAMGF LEPGTQLRWM AALAVVIAFC 
121:	SASQDIVFDA WKTDVLPAEE RGAGAAISVL GYRLGMLVSG GLALWLADKW LGWQGMYWLM 
181:	AALLIPCIIA TLLAPEPTDT IPVPKTLEQA VVAPLRDFFG RNNAWLILLL IVLYKLGDAF 
241:	AMSLTTTFLI RGVGFDAGEV GVVNKTLGLL ATIVGALYGG ILMQRLSLFR ALLIFGILQG 
301:	ASNAGYWLLS ITDKHLYSMG AAVFFENLCG GMGTSAFVAL LMTLCNKSFS ATQFALLSAL 
361:	SAVGRVYVGP VAGWFVEAHG WSTFYLFSVA AAVPGLILLL VCRQTLEYTR VNDNFISRTA 
421:	YPAGYAFAMW TLAAGVSLLA VWLLLLTMDA LDLTHFSFLP ALLEVGVLVA LSGVVLGGLL 
481:	DYLALRKTHL T