TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.28.1
Cell surface receptor (c-receptor) for anemia-inducing feline leukemia virus subgroup C (FLCVR); functions in haem export in haemopoietic cells (Latunde-Dada et al., 2006Khan and Quigley, 2011). May cause Diamond-Blackfan anemia when defective (Keel et al., 2008). Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity (Yanatori et al., 2012). Heme accumulation causes toxicity.  FLVCR1 is co-induced upon iron insufficiency in the placenta with the LDL recpetor-related protein 1 (LRP1) heme receptor, and these two proteins may be important for neonatal iron status (Cao et al. 2014).  It is required for erythroid and αβ-, CD4 and CD8 T- cell development (Philip et al. 2015).

Accession Number:Q9Y5Y0
Protein Name:C10
Length:555
Molecular Weight:59863.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate D-glucose, Dehydroascorbate, arsenite, Quercetin, water

Cross database links:

Genevestigator: Q9Y5Y0
HEGENOM: HBG314332
RefSeq: NP_054772.1   
Entrez Gene ID: 28982   
Pfam: PF07690   
OMIM: 609144  gene
KEGG: hsa:28982   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (7)

[1] “A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily.”  Tailor C.S.et.al.   10400745
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus.”  Lipovich L.et.al.   11943475
[5] “Identification of a human heme exporter that is essential for erythropoiesis.”  Quigley J.G.et.al.   15369674
[6] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[7] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN GAPRDSLAAA 
61:	SGVLGGPQTP LAPEEETQAR LLPAGAGAET PGAESSPLPL TALSPRRFVV LLIFSLYSLV 
121:	NAFQWIQYSI ISNVFEGFYG VTLLHIDWLS MVYMLAYVPL IFPATWLLDT RGLRLTALLG 
181:	SGLNCLGAWI KCGSVQQHLF WVTMLGQCLC SVAQVFILGL PSRIASVWFG PKEVSTACAT 
241:	AVLGNQLGTA VGFLLPPVLV PNTQNDTNLL ACNISTMFYG TSAVATLLFI LTAIAFKEKP 
301:	RYPPSQAQAA LQDSPPEEYS YKKSIRNLFK NIPFVLLLIT YGIMTGAFYS VSTLLNQMIL 
361:	TYYEGEEVNA GRIGLTLVVA GMVGSILCGL WLDYTKTYKQ TTLIVYILSF IGMVIFTFTL 
421:	DLRYIIIVFV TGGVLGFFMT GYLPLGFEFA VEITYPESEG TSSGLLNASA QIFGILFTLA 
481:	QGKLTSDYGP KAGNIFLCVW MFIGIILTAL IKSDLRRHNI NIGITNVDVK AIPADSPTDQ 
541:	EPKTVMLSKQ SESAI