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2.A.1.28.4
The Fowler syndrome-associated protein, feline leukemia virus subgroup C receptor-related protein 2, is a heme importer (Duffy et al., 2010).

Accession Number:Q9UPI3
Protein Name:Feline leukemia virus subgroup C receptor-related protein 2
Length:526
Molecular Weight:57241.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

Genevestigator: Q9UPI3
eggNOG: prNOG06165
HEGENOM: HBG314332
Entrez Gene ID: 55640   
Pfam: PF07690   
KEGG: hsa:55640   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0020037 F:heme binding
GO:0015232 F:heme transporter activity
GO:0055085 P:transmembrane transport

References (8)

[1] “Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis.”  Brasier G.et.al.   14729055
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The Fowler syndrome-associated protein FLVCR2 is an importer of heme.”  Duffy S.P.et.al.   20823265
[6] “Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome).”  Meyer E.et.al.   20206334
[7] “Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing.”  Lalonde E.et.al.   20518025
[8] “High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy.”  Thomas S.et.al.   20690116

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVNEGPNQEE SDDTPVPESA LQADPSVSVH PSVSVHPSVS INPSVSVHPS SSAHPSALAQ 
61:	PSGLAHPSSS GPEDLSVIKV SRRRWAVVLV FSCYSMCNSF QWIQYGSINN IFMHFYGVSA 
121:	FAIDWLSMCY MLTYIPLLLP VAWLLEKFGL RTIALTGSAL NCLGAWVKLG SLKPHLFPVT 
181:	VVGQLICSVA QVFILGMPSR IASVWFGANE VSTACSVAVF GNQLGIAIGF LVPPVLVPNI 
241:	EDRDELAYHI SIMFYIIGGV ATLLLILVII VFKEKPKYPP SRAQSLSYAL TSPDASYLGS 
301:	IARLFKNLNF VLLVITYGLN AGAFYALSTL LNRMVIWHYP GEEVNAGRIG LTIVIAGMLG 
361:	AVISGIWLDR SKTYKETTLV VYIMTLVGMV VYTFTLNLGH LWVVFITAGT MGFFMTGYLP 
421:	LGFEFAVELT YPESEGISSG LLNISAQVFG IIFTISQGQI IDNYGTKPGN IFLCVFLTLG 
481:	AALTAFIKAD LRRQKANKET LENKLQEEEE ESNTSKVPTA VSEDHL