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2.A.1.3.12
Tetracenomycin:H+ antiporter

Accession Number:P39886
Protein Name:TcmA
Length:538
Molecular Weight:54846.00
Species:Streptomyces glaucescens [1907]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Tetracenomycin, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0017000 P:antibiotic biosynthetic process
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (1)

[1] “Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci.”  Guilfoile P.G.et.al.   1592819

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTETHDEPS GVAHTPASGL RGRPWPTLLA VAVGVMMVAL DSTIVAIANP AIQQDLHASL 
61:	ADVQWITNGY LLALAVSLIT AGKLGDRFGH RQTFLVGVAG FAVTSAAIGL SGSVAAIVVF 
121:	RVLQGLFGAL MQPSALGLLR VTFPPGKLNM AIGIWSGVVG ASTAAGPIIG GLLVQHVGWE 
181:	AVFFINVPVG LAALVAGLVI LTDARAERAP KSFDVSGIVL LSGAMFCLVW GLIKAPAWGW 
241:	GDLRTLGFLA AAVLAFAGFT LRESRATEPL MPLAMFRSVP LSAGTVLMVL MAFSFIGGLF 
301:	FVTFYLQNVH GMSPVESGVH LLPLTGMMIV GAPVSGIVIS RFGPGGPLVV GMLLTAASLW 
361:	GMSTLEADSG MGITSLWFVL LGLGLAPVMV GTTDVIVSNA PAELAGVAGG LQQSAMQVGG 
421:	SLGTAVLGVL MASRVGDVFP DKWAEANLPR VGPREAAAIE DAAEVGAVPP AGTLPGRHAG 
481:	TLSEVVHSSF ISGMGLAFTV AGAVALVAAA VALFTRKAEP DERAPEEFPV PASTAGRG