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2.A.1.3.14
Methylviologen (paraquat):H+ antiporter, SmvA (also exports ethidium bromide, acriflavin, malachite green, pyronine B and benzyl viologen) (Villagra et al. 2008).

Accession Number:P37594
Protein Name:SmvA aka STM1574
Length:495
Molecular Weight:52134.00
Species:Salmonella typhimurium [90371]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Methylviologen, H+, Benzyl viologen, Malachite green, ethidium bromide, Pyonine B, acriflavin

Cross database links:

HEGENOM: HBG679341
RefSeq: NP_460533.1   
Entrez Gene ID: 1253092   
Pfam: PF07690   
BioCyc: STYP99287:STM1574-MONOMER   
KEGG: stm:STM1574   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The methyl viologen-resistance-encoding gene smvA of Salmonella typhimurium.”  Hongo E.et.al.   7926834
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFRQWLTLVI IVLVYIPVAI DATVLHVAAP TLSMTLGASG NELLWIIDIY SLVMAGMVLP 
61:	MGALGDRIGF KRLLMLGGTL FGLASLAAAF SHTASWLIAT RVLLAIGAAM IVPATLAGIR 
121:	ATFCEEKHRN MALGVWAAVG SGGAAFGPLI GGILLEHFYW GSVFLINVPI VLVVMGLTAR 
181:	YVPRQAGRRD QPLNLGHAVM LIIAILLLVY SAKTALKGHL SLWVISFTLL TGALLLGLFI 
241:	RTQLATSRPM IDMRLFTHRI ILSGVVMAMT AMITLVGFEL LMAQELQFVH GLSPYEAGVF 
301:	MLPVMVASGF SGPIAGVLVS RLGLRLVATG GMALSALSFY GLAMTDFSTQ QWQAWGLMAL 
361:	LGFSAASALL ASTSAIMAAA PAEKAAAAGA IETMAYELGA GLGIAIFGLL LSRSFSASIR 
421:	LPAGLEAQEI ARASSSMGEA VQLANSLPPT QGQAILDAAR HAFIWSHSVA LSSAGSMLLL 
481:	LAVGMWFSLA KAQRR