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2.A.1.3.15
Rifamycin:H+ antiporter

Accession Number:O52557
Protein Name:RifP
Length:522
Molecular Weight:53209.00
Species:Amycolatopsis mediterranei (Nocardia mediterranei) [33910]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Rifamycin, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.”  August P.R.et.al.   9512878
[2] “3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.”  Kim C.G.et.al.   9497318
[3] “Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.”  Yu T.W.et.al.   11278540

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHATAAVTET RNPRRWLILA VISLAQLVVL VDNTVLNLAI PKLTEDLGAT TADIQWMINA 
61:	YALVQSGLLL TAGSFSDRYG RKRSLLAGLL LFGVGSLAAA FSLSSGQLIA ARAGMGIGGA 
121:	LLTTTTLAVV MQVFDEKELP KAIGLWSAVS SFGYASGPLI GGALLAHFWW GSIFLINIPV 
181:	ALLGCVAVAK LVPESKDPQG ARPDLVGAAL STIGMAGIVY AIISGPEHGW ASATVLVAAG 
241:	IGVAALAAFV RWELHVPHPM LDMGLFRNRR FNGAISGGLL VAFGMGGSVF LLTQQLQLVL 
301:	GYDPLEAGLR TAPLALVVVA LNVAGLGAKL LEKLGIAMTI AVGMTLNAVG LAMVAVLGTP 
361:	DRGFGGMLAC LLVMGGGIAP AMPAMANAIM TSIPAEKAGA GAAVQGTVNQ FGSGLGVAIL 
421:	GAVLNSRFAA LLPIGLGAGA AGSLHEALLQ ARTPALQAQV RDAFAGGVRA SELIGALAVV 
481:	LGGMLAGMLL RRAARSEAHQ AAWARPTIRL EAAPAPFTVD LR