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2.A.1.3.17
The trimethoprim-sensitivity protein, YebQ (increases sensitivity to trimethoprim)

Accession Number:P76269
Protein Name:YebQ aka B1828
Length:457
Molecular Weight:48152.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Trimethoprim

Cross database links:

Genevestigator: P76269
EchoBASE: EB3773
EcoGene: EG14019
eggNOG: COG0477
HEGENOM: HBG679341
RefSeq: AP_002448.1    NP_416342.4   
Entrez Gene ID: 946048   
Pfam: PF07690   
BioCyc: EcoCyc:B1828-MONOMER    ECOL168927:B1828-MONOMER   
KEGG: ecj:JW5299    eco:b1828   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (3)

[1] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKVQADGLP LPQRYGAILT IVIGISMAVL DGAIANVALP TIATDLHATP ASSIWVVNAY 
61:	QIAIVISLLS FSFLGDMFGY RRIYKCGLVV FLLSSLFCAL SDSLQMLTLA RVIQGFGGAA 
121:	LMSVNTALIR LIYPQRFLGR GMGINSFIVA VSSAAGPTIA AAILSIASWK WLFLINVPLG 
181:	IIALLLAMRF LPPNGSRASK PRFDLPSAVM NALTFGLLIT ALSGFAQGQS LTLIAAELVV 
241:	MVVVGIFFIR RQLSLPVPLL PVDLLRIPLF SLSICTSVCS FCAQMLAMVS LPFYLQTVLG 
301:	RSEVETGLLL TPWPLATMVM APLAGYLIER VHAGLLGALG LFIMAAGLFS LVLLPASPAD 
361:	INIIWPMILC GAGFGLFQSP NNHTIITSAP RERSGGASGM LGTARLLGQS SGAALVALML 
421:	NQFGDNGTHV SLMAAAILAV IAACVSGLRI TQPRSRA