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2.A.1.3.22
The Tet38 tetracycline-resistance protein of Staphylococcus aureus (Truong-Bolduc et al., 2005)

Accession Number:Q5PU79
Protein Name:Tetracycline resistant protein Tet38
Length:450
Molecular Weight:49403.00
Species:Staphylococcus aureus [1280]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (1)

[1] “MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.”  Truong-Bolduc Q.C.et.al.   15774883

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNVEYSKIKK AVPILLFLFV FSLVIDNSFK LISVAIADDL NISVTTVSWQ ATLAGLVIGI 
61:	GAVVYASLSD AISIRTLFIY GVILIIIGSI IGYIFQHQFP LLLVGRIIQT AGLAAAETLY 
121:	VIYVAKYLSK EDQKTYLGLS TSSYSLSLVI GTLSGGFIST YLHWTNMFLI ALIVVFTLPF 
181:	LFKLLPKENN TNKAHLDFVG LILVATIATT VMLFITNFNW LYMIGALIAI IVFALYIKNA 
241:	QRPLVNKSFF QNKRYASFLF IVFVMYAIQL GYIFTFPFIM EQIYHLQLDT TSLLLVPGYI 
301:	VAVIVGALSG KIGEYLNSKQ AIITAIILIA LSLILPAFAV GNHISIFVIS MIFFAGSFAL 
361:	MYAPLLNEAI KTIDLNMTGV AIGFYNLIIN VAVSVGIAIA AALIDFKALN FPGNDALSSH 
421:	FGIILIILGL MSIVGLVLFV ILNRWTQSEK