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2.A.1.3.23
The NorB multidrug resistance pump (exports hydrophilic quinolones, ethidium bromide, cetrimide, sparfloxacin, moxifloxacin and tetracycline) (Truong-Bolduc et al., 2005)

Accession Number:Q7A5M0
Protein Name:NorB aka Blt-like protein
Length:463
Molecular Weight:49273.00
Species:Staphylococcus aureus (strain N315) [158879]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hydrophilic quinolones, ethidium bromide, Sparfloxacin, Moxifloxacin, tetracycline, Cetrimide

Cross database links:

eggNOG: COG0477
HEGENOM: HBG309849
RefSeq: NP_374550.1   
Entrez Gene ID: 1124107   
Pfam: PF07690   
BioCyc: SAUR158879:SA1269-MONOMER   
KEGG: sau:SA1269   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKPSREAFE GNNKLLIGIV LSVITFWLFA QSLVNVVPIL EDSFNTDIGT VNIAVSITAL 
61:	FSGMFVVGAG GLADKYGRIK LTNIGIILNI LGSLLIIISN IPLLLIIGRL IQGLSAACIM 
121:	PATLSIIKSY YIGKDRQRAL SYWSIGSWGG SGVCSFFGGA VATLLGWRWI FILSIIISLI 
181:	ALFLIKGTPE TKSKSISLNK FDIKGLVLLV IMLLTLNILI TKGSELGVTS LLFITLLAIA 
241:	IGSFSLFIVL EKRATNPLID FKLFKNKAYT GATASNFLLN GVAGTLIVAN TFVQRGLGYS 
301:	SLQAGSLSIT YLVMVLIMIR VGEKLLQTLG CKKPMLIGTG VLIVGECLIS LTFLPEILYV 
361:	ICCIIGYLFF GLGLGIYATP STDTAIANAP LEKVGVAAGI YKMASALGGA FGVALSGAVY 
421:	AIVSNMTNIY TGAMIALWLN AGMGILSFVI ILLLVPKQND TQL