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2.A.1.3.25
Actinorhodin (blue pigmented antibiiotic) transporter, ActII-2

Accession Number:P46105
Protein Name:Probable actinorhodin transporter
Length:578
Molecular Weight:59772.00
Species:Streptomyces coelicolor [1902]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Actinorhodin

Cross database links:

HEGENOM: HBG679341
Entrez Gene ID: 1100524   
Pfam: PF07690   
KEGG: sco:SCO5083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (2)

[1] “The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.”  Fernandez-Moreno M.A.et.al.   1878971
[2] “Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).”  Bentley S.D.et.al.   12000953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSVEADEPD RATAPPSALL PEDGPGPDGT AAGPPPYARR WAALGVILGA EIMDLLDGTV 
61:	MNVAAPAVRA DLGGSLSVIQ WITVGYTLAF AVLLVVGGRL GDIYGRKRMF VVGAVGFTAA 
121:	SVLCSVAAGP EMLTAARFLQ GGLGALMIPQ GLGLIKQMFP PKETAAAFGA FGPAIGLGAV 
181:	LGPIVAGFLV DADLFGTGWR SVFLINLPIG VAVIVGAVLL LPEGKAPVRP KFDVVGMALV 
241:	TSGLTLLIFP LVQGRERGWP AWAFVLMLAG AAVLVGFVAH ELRQERRGGA TLIELSLLRR 
301:	SRYAAGLAVA LVFFTGVSGM SLLLALHLQI GLGFSPTRAA LTMTPWSVFL VVGAILTGAV 
361:	LGSKFGRKAL HGGLVVLALG VLIMLLTIGD QAGGLTSWEL VPGIAVAGLG MGIMIGLLFD 
421:	IALADVDKQE AGTASGVLTA VQQLGFTVGV AVLGTLFFGL LGSQATASVD DGASRARTEL 
481:	AAAGASTTEQ DRLLADLRVC LRESASQQDS ERTPDSCRNL QQARPAVAEA TARAWRTAHT 
541:	ENFSTAMVRT LWVVIALLAV SFALAFRLPP KPREEEGF