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2.A.1.3.28
MDR multidrug efflux pump, EbrE (involved in colony growth, dependent on Ca2+, Mg2+, Na+ and K+) (Lee et al., 2007)

Accession Number:Q939A4
Protein Name:EbrE
Length:521
Molecular Weight:53747.00
Species:Streptomyces lividans [1916]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0055085 P:transmembrane transport

References (1)

[1] “Repressed multidrug resistance genes in Streptomyces lividans.”  Lee L.F.et.al.   12937892

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRTVAAMTTN PPRAGRREWT ALAVLMLPLL LVSMDVSVLF FAIPEISADL EPSGTQQLWI 
61:	FDIYGFVLAG LLMTMGSLGD RIGRRRLLLV GAAAFGAASL LAAYAHTAET LIAARAVLGI 
121:	GGATLMPSTM ALVRTMFTDP AQRAKAIGLW SGVMTAGIAL GSVMSGVLVE HFWWGSVFLV 
181:	NLPAMALLLI LGPMLLPESK NPSPGRFDLL SVPLSMAAVL PVVYGLKELP SEGWNVRYVV 
241:	SITVGLLFAA LFVHRQRTAA SPMISPALFR GHGFTPAVVL NLVSAFGMMG SSYFTTQYLQ 
301:	SVLDKSALEA ALWALLPSVF IGFAAPLAMR LVQLGVERAY VVAGGFVVAA CGYALLACAG 
361:	TDSLWLVLAA CGVMAGGIVA VMSQLTDLAL SSAPVEKAGA ASSLMETGTE FGGALSMAVL 
421:	GSVGTAVYHH EMPASAPDAA RETLGGALSV AARLPGSAGE ALATAAREAF TDGMRGASIA 
481:	GAVLLLAAAL PAARALRGIR VRENAATENA GQADSLSPSG V