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2.A.1.3.29
The metal:tetracycline/oxytetracycline resistance efflux pump, TctB (563 aas)

Accession Number:O69070
Protein Name:Tetracycline efflux protein aka TctB
Length:563
Molecular Weight:58809.00
Species:Streptomyces rimosus [1927]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Me2+-tetracycline, Oxytetracycline

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport

References (1)

[1] “Revised sequence of OtrB (tet347) tetracycline efflux protein from Streptomyces rimosus.”  McMurry L.M.et.al.   9867793

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSANPGPAG TADQAGGAFT HRQILTAMSG LLLAVFLAAL DQTVIATAMR TIADDLHGQT 
61:	EQAWATTGYL IASVLAMPFY GKLSDIYGRK PMYLISIVVF IGGSVLCGTA GSMWELALFR 
121:	AVQGLGGGGL MSLPTAVVAD LAPVRERGRY FAFLQMAWVV ASVAGPLAGG FFAEAGQVFG 
181:	IDGWRWVFLL NVPLGLLALV TVRKALNLPH ERREHRMDVL GAAALALFLV PLLIVAEQGR 
241:	TWGWGSPAAL ALFALGAAGL AVFIPVELRR GDEAILPLGL FRRGSIALCS AVNFTIGVGI 
301:	FGTVTTLPLF LQMVQGRTPT QAGLVVIPFM LGTIASQMVS GKLIASSGRF KKLAIVGLGS 
361:	MAGALLAMAT TGATTPMWGI VLIVLWLGVG IGLSQTVITS PMQNSAPKSQ LGVANGASGL 
421:	CRQIGGSTGI AVLFSVMFAV ALGRLADLLH TPRYERLLTD PAITGDPANH RFLDMAESGQ 
481:	GAGINLDDTS LLNGIDARLM QPVTDSFAHG FHIMFLAGGV VLLAGFVMTW FLRELQEETA 
541:	PEEERPAESG AGAKNGPLPA SDA