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2.A.1.3.3
(Acriflavin, ethidium bromide, fluoroquinolones, etc.):H+ antiporter (Li et al. 2004; Rodrigues et al. 2011).

Accession Number:Q50392
Protein Name:LfrA
Length:504
Molecular Weight:51540.00
Species:Mycobacterium smegmatis [1772]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate acriflavin, ethidium bromide, Fluoroquinolones

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0055085 P:transmembrane transport

References (1)

[1] “Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.”  Takiff H.E.et.al.   8552639

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTCIEGTPS TTRTPTRAWV ALAVLALPVL LIAIDNTVLA FALPLIAEDF RPSATTQLWI 
61:	VDVYSLVLAA LLVAMGSLGD RLGRRRVLLI GGAGFAVVSA LAAFAPSTEL LVGARALLGV 
121:	FGAMLMPSTL SLIRNIFTDA SARRLAIAIW ASCFTAGSAL GPIVGGALLE HFHWGAVFLV 
181:	AVPILLPLLV LGPRLVPESR DPNPGPFDPV SIVLSFTTML PIVWAVKTAA HDGLSAAAAA 
241:	AFAVGIVSGA LFVRRQNRSA TPMLDIGLFK VMPFTSSILA NFLSIIGLIG FIFFISQHLQ 
301:	LVLGLSPLTA GLVTLPGAVV SMIAGLAVVK AAKRFAPDTL MVTGLVFVAV GFLMILLFRH 
361:	NLTVAAIIAS FVVLELGVGV SQTVSNDTIV ASVPAAKSGA ASAVSETAYE LGAVVGTATL 
421:	GTIFTAFYRS NVDVPAGLTP EQTGAAAESI GGAAAVAADL PAATATQLLD SARAAFDSGI 
481:	APTAVIAAML VLAAAAVVGV AFRR