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2.A.1.3.30
Lincomycin resistance protein; Lincomycin:H+ antiporter, LmrB

Accession Number:O35018
Protein Name:LmrB
Length:479
Molecular Weight:51709.00
Species:Bacillus subtilis [1423]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

HEGENOM: HBG679341
RefSeq: NP_388149.1   
Entrez Gene ID: 938388   
Pfam: PF07690   
KEGG: bsu:BSU02670   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation.”  Kumano M.et.al.   9274031
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MILETTAKAS QQYKVMPIMI SLLLAGFIGM FSETALNIAL TDLMKELNIT AATVQWLTTG 
61:	YLLVLGILVP VSGLLLQWFT TRQLFTVSLI FSILGTFIAA LAPSFSFLLA ARIVQALGTG 
121:	LLLPLMFNTI LVIFPPHKRG AAMGTIGLVI MFAPAIGPTF SGLVLEHLNW HWIFWISLPF 
181:	LVLALVFGIA YMQNVSETTK PKIDVLSIIL STIGFGGIVF GFSNAGEGSG GWSSPTVIVS 
241:	LIVGVVGLIL FSIRQLTMKQ PMMNLRAFKY PMFILGVIMV FICMMVILSS MLLLPMYLQG 
301:	GLVLTAFASG LVLLPGGILN GFMSPVTGRL FDKYGPKWLV IPGFVIVTVV LWFFSNVTTT 
361:	STAVLIIILH TCLMIGISMI MMPAQTNGLN QLPREFYPDG TAIMNTLQQM AGAIGTAVAV 
421:	SIMAAGQHDY MSTVKNPADP AVIPQALTAG VQHAFVFAMI VAIIGLIGAF FMKRVKVDH