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2.A.1.3.31
The hydrophilic fluoroquinolones efflux pump, QepA (Perichon et al., 2008). Exports hydrophilic quinolones, norfloxacin, and ciprofloxacin.

Accession Number:A5H8A5
Protein Name:QepA
Length:511
Molecular Weight:53114.00
Species:Escherichia coli [562]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hydrophilic fluoroquinolones, norfloxacin, Ciprofloxacin

Cross database links:

RefSeq: YP_001816613.1   
Entrez Gene ID: 6275948   
Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli.”  Perichon B.et.al.   17470656
[2] “New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.”  Yamane K.et.al.   17548499
[3] “Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates.”  Bercot B.et.al.   18838598

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSATLHDTAA DRRKATRREW IGLAVVALPC LVYAMDLTVL NLALPVLSRE LQPSSAQLLW 
61:	ILDIYGFFVA GFLITMGTLG DRIGRRRLLL IGAAFFAFAS VLAALADTAA LLIAARALLG 
121:	LAGATIAPST MALVRNMFHD PRQRQFAIGV WIAAFSLGSA IGPLVGGVLL EFFHWGAVFW 
181:	LNVPVMLLTL ALGPRFLPEY RDPDAGHLDL ASVLLSLAAV LLTIYGLKQL AEHGAGLASM 
241:	AALLAGLAVG ALFLRRQGHI AYPLLDLRLF AHAPFRAALA AYALAALAMF GVYIFMTQYL 
301:	QLVLGLSPLQ AGLATLPWSL CFVIGSLLSP QLAARWPAAR ILVVGLSAAA FGFAVLGLGQ 
361:	GLWWLVPATI VMGLGLAPVF TIGNEIIITS APSERAGAAS ALSETVSEFS GALGIALFGS 
421:	VGLVVYRQAL TSAALPGLPA DALQAAGASL GGAVHLADTL PAWQGAALLA AARAGFTDAL 
481:	QATAWAGAVL VLVAAGLVAR LLRKRPALAS G