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2.A.1.3.33
Multidrug (including novobiocin, streptomycin, and actinomycin D) resistance porter, MdtP (YusP)

Accession Number:O32182
Protein Name:Uncharacterized MFS-type transporter yusP
Length:541
Molecular Weight:57946.00
Species:Bacillus subtilis [1423]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Novobiocin, Streptomycin, Actinomycin D

Cross database links:

HEGENOM: HBG679341
RefSeq: NP_391167.1   
Entrez Gene ID: 937088   
Pfam: PF07690   
BioCyc: SUBTI:BSU32880-MONOMER   
KEGG: bsu:BSU32880   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKMSKEGKQS KRTLLITGLI IAMFFSALDG TIVGTAMPKI VGDLGGLSMM TWLTTAYLLT 
61:	STTIVPIAGK LADLLGRRIV YVSGLIIFMA ASALCGMANN MTELIIFRGL QGIGGGIMMP 
121:	MAMIVIGDLF TGKQRAKFQG VFGAIYGLAS VIGPQIGGWI VDSLNWKWVF YINLPVGIIA 
181:	VIFIARGLQG RQQTGPINFD IAGIFTMIVG VVSLLLALSF GGKDYAWDSW QILGLFALAL 
241:	IGIVSFIIVE SKAKEPILPM YLFKNRTFTF LNLIGFFMSI GMFGAITFVP FFMQGIVGVS 
301:	ASESGTIMTP MMISMIITSI IGGQLVYKIG IKPQIITGML VMAGGFLLLT TLDLDTSKLV 
361:	ATSFMAIIGL GMGLVMPILT LALQESFSKE ELGVVTSSSQ FFRSIGGTFG ITMLGAVMNA 
421:	RSGNLLTDKL VPYLDSLPAQ ASSFAAQLKG MIDTNPQGLL QSLFSPDAVK QIPAAFSSHI 
481:	VPILKTSLMD SLHSVFYTGL IFIAVGAVFT LFLKPIKLSN KKAEDQQEKE KAAKAVESPS 
541:	H