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2.A.1.3.34
The P55 drug efflux pump (Rv141Oc) (extrudes drugs including rifampicin and clifazimine, first- and second-line anti-tuberculosis drugs. CCCP and valinomycin inhibited drug resistance) (Ramón-García et al., 2009).  P55 also exports malachite green, ethidium bromide, isoniazid and ethambutol (Bianco et al. 2011).  Functions together with the outer membrane lipoprotein porin, LprG, also called P27 and Lpp-27 (Bianco et al. 2011; Farrow and Rubin 2008).  Required together with LprG for normal colony morphology and sliding motility, possibly due to alterred cell wall composition (Farrow and Rubin 2008).  Required together with LprG for normal colony morphology and sliding motility, possibly due to alterred cell wall composition (Farrow and Rubin 2008).

Accession Number:P71678
Protein Name:Rv1410c
Length:518
Molecular Weight:54689.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Rifampicin, Clifazimine, CCCP, Valinomycin, Malachite green, ethidium bromide, isoniazid, Ethambutol

Cross database links:

HEGENOM: HBG564689
RefSeq: NP_215926.1    NP_335905.1   
Entrez Gene ID: 886709    924518   
Pfam: PF07690   
KEGG: mtc:MT1454    mtu:Rv1410c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (3)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein.”  Farrow M.F.et.al.   18156250

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FASTA formatted sequence
1:	MRAGRRVAIS AGSLAVLLGA LDTYVVVTIM RDIMNSVGIP INQLHRITWI VTMYLLGYIA 
61:	AMPLLGRASD RFGRKLMLQV SLAGFIIGSV VTALAGHFGD FHMLIAGRTI QGVASGALLP 
121:	ITLALGADLW SQRNRAGVLG GIGAAQELGS VLGPLYGIFI VWLLHDWRDV FWINVPLTAI 
181:	AMVMIHFSLP SHDRSTEPER VDLVGGLLLA LALGLAVIGL YNPNPDGKHV LPDYGAPLLV 
241:	GALVAAVAFF GWERFARTRL IDPAGVHFRP FLSALGASVA AGAALMVTLV DVELFGQGVL 
301:	QMDQAQAAGM LLWFLIALPI GAVTGGWIAT RAGDRAVAFA GLLIAAYGYW LISHWPVDLL 
361:	ADRHNILGLF TVPAMHTDLV VAGLGLGLVI GPLSSATLRV VPSAQHGIAS AAVVVARMTG 
421:	MLIGVAALSA WGLYRFNQIL AGLSAAIPPN ASLLERAAAI GARYQQAFAL MYGEIFTITA 
481:	IVCVFGAVLG LLISGRKEHA DEPEVQEQPT LAPQVEPL