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2.A.1.3.39
The antimicrobial efflux pump, LmrS. Exports linezolid and tetraphenylphosphonium chloride (TPCL) > sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. (most similar to LmrB (2.A.1.3.30)) (Floyd et al., 2010).

Accession Number:Q5HE38
Protein Name:Drug resistance transporter, EmrB/QacA subfamily
Length:480
Molecular Weight:52638.00
Species:Staphylococcus aureus (strain COL) [93062]
Number of TMSs:14
Substrate Linezold, Tetraphenylphosphonium chloride, SDS, Trimethoprim, Chloramphenicol

Cross database links:

eggNOG: COG0477
HEGENOM: HBG679341
Entrez Gene ID: 3237419   
Pfam: PF07690   
KEGG: sac:SACOL2157   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (1)

[1] “Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.”  Gill S.R.et.al.   15774886

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKVELTTRR RNFIVAVMLI SAFVAILNQT LLNTALPSIM RELNINESTS QWLVTGFMLV 
61:	NGVMIPLTAY LMDRIKTRPL YLAAMGTFLL GSIVAALAPN FGVLMLARVI QAMGAGVLMP 
121:	LMQFTLFTLF SKEHRGFAMG LAGLVIQFAP AIGPTVTGLI IDQASWRVPF IIIVGIAILA 
181:	FVFGLVSISS YNEVKYTKLD KRSVMYSTIG FGLMLYAFSS AGDLGFTSPI VIGALILSMV 
241:	IIYLFIRRQF NITNALLNLR VFKNRTFALC TISSMIIMMS MVGPALLIPL YVQNSLSLSA 
301:	LLSGLVIMPG AIINGIMSVF TGKFYDKYGP RPLIYTGFTI LTITTIMLCF LHTDTSYTYL 
361:	IVVYAIRMFS VSLLMMPINT TGINSLRNEE ISHGTAIMNF GRVMAGSLGT ALMVTLMSFG 
421:	AKIFLSTSPS HLTATEIKQQ SIAIGVDISF AFVAVLVMAA YVIALFIREP KEIESNRRKF