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2.A.1.3.4
(Mono- and divalent organocation):H+ antiporter. Transmembrane helix 12 of QacA lines the bivalent cationic drug binding pocket (Hassan et al., 2007).

Accession Number:P0A0J9
Protein Name:Antiseptic resistance protein QacA aka SAVP032
Length:514
Molecular Weight:55016.00
Species:Staphylococcus aureus [1280]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: YP_536864.1   
Entrez Gene ID: 3978608   
Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (2)

[1] “Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.”  Rouch D.A.et.al.   2089219
[2] “Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.”  Paulsen I.T.et.al.   8622987

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MISFFTKTTD MMTSKKRWTA LVVLAVSLFV VTMDMTILIM ALPELVRELE PSGTQQLWIV 
61:	DIYSLVLAGF IIPLSAFADK WGRKKALLTG FALFGLVSLA IFFAESAEFV IAIRFLLGIA 
121:	GALIMPTTLS MIRVIFENPK ERATALAVWS IASSIGAVFG PIIGGALLEQ FSWHSAFLIN 
181:	VPFAIIAVVA GLFLLPESKL SKEKSHSWDI PSTILSIAGM IGLVWSIKEF SKEGLADIIP 
241:	WVVIVLAITM IVIFVKRNLS SSDPMLDVRL FKKRSFSAGT IAAFMTMFAM ASVLLLASQW 
301:	LQVVEELSPF KAGLYLLPMA IGDMVFAPIA PGLAARFGPK IVLPSGIGIA AIGMFIMYFF 
361:	GHPLSYSTMA LALILVGAGM ASLAVASALI MLETPTSKAG NAAAVEESMY DLGNVFGVAV 
421:	LGSLSSMLYR VFLDISSFSS KGIVGDLAHV AEESVVGAVE VAKATGIKQL ANEAVTSFND 
481:	AFVATALVGG IIMIIISIVV YLLIPKSLDI TKQK