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2.A.1.3.48
Probable multidrug-efflux transporter Rv1634/MT1670

Accession Number:O06151
Protein Name:Probable multidrug-efflux transporter Rv1634/MT1670
Length:471
Molecular Weight:47713.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: COG0477
HEGENOM: HOG000046190
Entrez Gene ID: 885115    924194   
Pfam: PF07690   
KEGG: mtc:MT1670    mtu:Rv1634   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015562 F:efflux transmembrane transporter activity
GO:0042891 P:antibiotic transport
GO:0046677 P:response to antibiotic

References (3)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.”  De Rossi E.et.al.   12520088

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTETASETGS WRELLSRYLG TSIVLAGGVA LYATNEFLTI SLLPSTIADI GGSRLYAWVT 
61:	TLYLVGSVVA ATTVNTMLLR VGARSSYLMG LAVFGLASLV CAAAPSMQIL VAGRTLQGIA 
121:	GGLLAGLGYA LINSTLPKSL WTRGSALVSA MWGVATLIGP ATGGLFAQLG LWRWAFGVMT 
181:	LLTALMAMLV PVALGAGGVG PGGETPVGST HKVPVWSLLL MGAAALAISV AALPNYLVQT 
241:	AGLLAAAALL VAVFVVVDWR IHAAVLPPSV FGSGPLKWIY LTMSVQMIAA MVDTYVPLFG 
301:	QRLGHLTPVA AGFLGAALAV GWTVGEVASA SLNSARVIGH VVAAAPLVMA SGLALGAVTQ 
361:	RADAPVGIIA LWALALLIIG TGIGIAWPHL TVRAMDSVAD PAESSAAAAA INVVQLISGA 
421:	FGAGLAGVVV NTAKGGEVAA ARGLYMAFTV LAAAGVIASY QATHRDRRLP R