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2.A.1.3.49
Multidrug resistance protein Stp (Spectinomycin tetracycline efflux pump)

Accession Number:P71879
Protein Name:Multidrug resistance protein stp
Length:537
Molecular Weight:57115.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Spectinomycin, tetracycline

Cross database links:

eggNOG: COG0477
HEGENOM: HOG000239124
Entrez Gene ID: 887274    924017   
Pfam: PF07690   
KEGG: mtc:MT2395    mtu:Rv2333c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (3)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG.”  Ramon-Garcia S.et.al.   17242035

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNRTQLLTLI ATGLGLFMIF LDALIVNVAL PDIQRSFAVG EDGLQWVVAS YSLGMAVFIM 
61:	SAATLADLDG RRRWYLIGVS LFTLGSIACG LAPSIAVLTT ARGAQGLGAA AVSVTSLALV 
121:	SAAFPEAKEK ARAIGIWTAI ASIGTTTGPT LGGLLVDQWG WRSIFYVNLP MGALVLFLTL 
181:	CYVEESCNER ARRFDLSGQL LFIVAVGALV YAVIEGPQIG WTSVQTIVML WTAAVGCALF 
241:	VWLERRSSNP MMDLTLFRDT SYALAIATIC TVFFAVYGML LLTTQFLQNV RGYTPSVTGL 
301:	MILPFSAAVA IVSPLVGHLV GRIGARVPIL AGLCMLMLGL LMLIFSEHRS SALVLVGLGL 
361:	CGSGVALCLT PITTVAMTAV PAERAGMASG IMSAQRAIGS TIGFAVLGSV LAAWLSATLE 
421:	PHLERAVPDP VQRHVLAEII IDSANPRAHV GGIVPRRHIE HRDPVAIAEE DFIEGIRVAL 
481:	LVATATLAVV FLAGWRWFPR DVHTAGSDLS ERLPTAMTVE CAVSHMPGAT WCRLWPA