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2.A.1.3.5
(Pristinamycin I and II, rifamycin, etc.):H+ antiporter

Accession Number:Q54806
Protein Name:Ptr
Length:501
Molecular Weight:50903.00
Species:Streptomyces pristinaespiralis [38300]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Pristinamycin I, Pristinamycin II, Rifamycin, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Molecular characterization and transcriptional analysis of a multidrug resistance gene cloned from the pristinamycin-producing organism, Streptomyces pristinaespiralis.”  Blanc V.et.al.   8596448

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTATTTETSK APSGGHPQRW LILGVICLAQ LTVLLDNTVL SVAIPSLTRE LHASTADIQW 
61:	MINAYSLVQS GLLLTAGNAA DRYGRRKMLV AGLALFGIGS LAAGLAQTSG QLIAARAGMG 
121:	VGGALLMTTT LAVVVQVFDE TERVKAIALW STVSSLGFAA GPLIGGVMLE HYWWGAIFLI 
181:	NIPVAVIGLV AVVLLVPESK NPQGDRPDLL GAVLSTIGMT AVVYAIISGP DHGWTSTQVL 
241:	ASAALGALFL GAFVFWELRI PYPMLDMHFF RNQRFIGAVA GAILVAFGMT GSLFLLTQHL 
301:	QFVLGYGALD AGLRTAPLAL TVVALNLTGM GARLLRIFGT PVTIAVGMAL VSGGLAAIAV 
361:	LGAGGYNGML LGLVVMGAGV ALSMPAMANA IMSAIPPEKA GVGAGINGTL AEFGNGLGVA 
421:	VLGAVLNSRF AALVPAAVGA TSLPAALAAA DDAGERARIS DAFASGLETS QLVGAVAVLA 
481:	GGLLAALLLR RAERADPPAK A