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2.A.1.3.52
Drug resistance protein YOR378W.  Does not export boron (Bozdag et al. 2011).

Accession Number:Q08902
Protein Name:Drug resistance protein YOR378W
Length:515
Molecular Weight:56110.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

Genevestigator: Q08902
eggNOG: COG0477
HEGENOM: HOG000174951
DIP: DIP-4051N
Entrez Gene ID: 854560   
Pfam: PF07690   
KEGG: sce:YOR378W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[2] “Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure.”  Schaus S.E.et.al.   11562456
[3] “New weakly expressed cell cycle-regulated genes in yeast.”  de Lichtenberg U.et.al.   16278933
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTSSSVTQK NLDTNAEALK KEDKVLSEFD IQDERPKSLL WESAFVGVLC SAQLMTQAGL 
61:	GQSLAPLHII GNSFGTTNAG QLSWFASAYS LTVGTFILIA GRLGDIFGHK KFFVLGFFWY 
121:	ALWSLLAGFS VYSNQIFFDC CRAFQGMGPA FLLPNAIAIL GRTYKPGRRK NMVFSLFGAS 
181:	APGGFFLGAV FSSMLGQLAW WPWAYWIMGI ACFVLAVAGY FVIPHTPMPS RDASSFKLLE 
241:	RIDFAGSVTG VVGLILFNFA WNQGPVVGWQ TPYTYALLIV GTFFLVIFAY IESRAAFPLL 
301:	PFAALSSDTA FVLSCIAAGW ASFGIWIFYT WQFMEDSRGQ TPLLSSAQFS PVAISGFCAA 
361:	VTTGFLLSHT PPSTVMLFAM TAFTVGTILI ATAPVHQTYW AQTFVSIIVM PWGMDMSFPA 
421:	ATIMLSDSMP HEHQGLAASL VNTVVNYSIS IGLGIAGTIE SRVNDGGAKP LKGYRCSWYM 
481:	GIGLSGLGIF VAATYAWSTF MKSKKRISEK QHFIE